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This training course is for project managers interested in using bioavailability assessment to decrease uncertainty in the risk assessment which may lead to reduced remedial action costs; and supports risk assessors in using bioavailability assessments.

Bioavailability of Contaminants in Soil: Considerations for Human Health Risk Assessment

Risk-based cleanup goals are often calculated assuming that chemicals present in soil are absorbed by humans, animals, and plants as efficiently as the chemicals dosed during the toxicity tests used to determine regulatory toxicity values (such as the Reference Dose or Cancer Slope Factor). This assumption can result in inaccurate exposure estimates and associated risks for some contaminated sites because the amount of a chemical absorbed (the chemical’s bioavailability) from contaminated soil can be a fraction of the total amount present. Properly accounting for soil-chemical interactions on the bioavailability of chemicals from soil can lead to more accurate estimates of exposures to soil contaminants and improve risk assessments by decreasing uncertainty.

The basis for this training course is the ITRC guidance: Bioavailability of Contaminants in Soil: Considerations for Human Health Risk Assessment (BCS-1). This guidance describes the general concepts of the bioavailability of contaminants in soil, reviews the state of the science, and discusses how to incorporate bioavailability into the human health risk assessment process. This guidance addresses lead, arsenic, and polycyclic aromatic hydrocarbons (PAHs) because evaluating bioavailability is better understood for these chemicals than for others, particularly for the incidental ingestion of soil.

The target audience for this guidance and training course are:

The target audience for this guidance and training course are:

Learners can envision themselves implementing the ITRC guidance through case study applications. Training participants are encouraged to view the associated ITRC guidance, Bioavailability of Contaminants in Soil: Considerations for Human Health Risk Assessment (BCS-1) prior to attending the class.

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