This guidance explains the processes controlling contaminant fate and transport in fractured rock, as well as innovative approaches to managing these sites. Additionally, this guidance describes how to develop a useful conceptual site model (CSM) and how to identify strategies to remediate and monitor contamination in fractured rock. Characterizing and remediating contaminated fractured rock sites must account for the complexities of structural control of contaminate fate and transport. Experience and a combination of skills from a number of disciplines is necessary to unravel inherent complexities of fracture flow and control. In as much as the process of characterization and remediation fractured rock is similar to an unlithified subsurface the investigation and tools differ. A Tool selection table is included to streamline the process of considering a set of tools able to collect the correct data.