This ITRC petroleum vapor intrusion (PVI) guidance document provides an 8-step process for the effective assessment and management of vapor intrusion at sites contaminated with petroleum hydrocarbons. The guidance presents a method of screening petroleum-contaminated sites for potential vapor intrusion, as well as providing the tools and strategies that offer the most efficient means of evaluating the vapor intrusion pathway at these sites. The fundamental principle of this screening method is the “vertical separation distance,” which was developed using empirical data from hundreds of petroleum-contaminated sites. Use of separation distance to screen petroleum-contaminated sites allows managers to better focus scarce resources on sites with greater potential for petroleum vapor intrusion.