This document provides interested parties—regardless of role (responsible parties, regulators,
stakeholders)—with practical information and guidance on how to systematically evaluate and
manage uncertainty associated with the remediation process by using remediation process optimization (RPO) as a tool. It provides guidance on what could and should be included in an effective RPO proposal or program, including what RPO is, the regulatory framework that RPO must operate within, and references that provide examples of successful RPOs and resources for further examination of RPO.