In situ remediation technologies have advanced to mainstream acceptance and offer a competitive advantage over many forms of ex situ treatment of soil and groundwater. Developing a detailed site-specific strategy is absolutely critical to the success of such in situ remedies. These strategies include conducting a thorough site characterization that will allow the development of a detailed Conceptual Site Model (CSM) to guide critical analysis of subsurface features and improve remediation effectiveness. In the interest of developing expedited solutions, many past in situ remediation projects have been executed based on an incomplete understanding of hydrogeology, geology, and contaminant distribution and mass. Some of these sites have undergone multiple rounds of in situ injections but have not advanced to closure. Better strategies and minimum design standards are required to decrease uncertainty and improve remedy effectiveness. This team developed guidance to help optimize remedial outcomes with in situ remedial strategies. To concisely summarize the issues surrounding the topic, the team created a guidance document on optimizing remediation performance and developing effective strategies and associated Internet-Based training, also on Clu-In. The document discusses the risks and limitations of these technologies, and how to address them to improve remedial success.